Development of proprietary medicines

We look for new medicines in oncology, neuropsychiatry, diabetology and virology

The development of innovative drugs at Adamed is focused on four therapeutic areas: diabetology, oncology, neuropsychiatry and virology. We have the capacity to vigorously execute highly complex projects, such as the development of new molecules, thanks to our multidisciplinary team of experts working in modern laboratories with advanced technological facilities.

 

Our laboratories enable agile application of technologies which are needed to select and test drug candidates and transfer them to the clinical development stage. We have the know-how to:

  1. produce small-molecule compounds using chemical synthesis, as well as biological molecules by employing chemical and biotechnological methods;
  2. analyze the same by chemical, biochemical and biophysical methods;
  3. study the functionality and efficiency of these molecules by cell or tissue biology methods;
  4. determine the potential of these molecules to progress to further stages of development by establishing their safety profile in toxicological studies, as well as pharmacokinetic and pharmacodynamic characteristics in in vivo methods.

In our research projects we also use advanced mathematical tools both for data analysis and for in silico modelling during the design phase and when optimizing the molecules which exhibit a therapeutic potential.

Currently, we are implementing projects focusing on six research programmes through which we have selected three molecules which are drug candidates at the stage of transfer to clinical trials. The first one is a licenced-out small molecule developed in indication mental disorders. The second one is a selective MDM2 and p53 protein inhibitor which exhibits cancer-fighting activity in sarcomas, lymphomas, and leukemias. The third molecule is a recombinant fusion protein with pro-apoptotic and anti-angiogenic activity. It is a drug candidate for solid tumors of the gastrointestinal tract.

In the other three research programmes we are in the process of selecting and optimizing molecules. In the first programme, these are anti-cancer molecules and in the other programme, molecules which are intended to be used for treatment of civilization diseases, such as type 2 diabetes and obesity, in the third, fast acting molecules in treatment of depression.

Pipeline

Discovery Lead optimisation Tox Phase I

Infectious diseases

Innovation Department Labs & Teams

Data Modelling & Analysis Lab
Biotechnology Lab
Proteomics Lab
Cell Biology Lab
Laboratory Animals Team
Preclinical Development Team
CNS Team
Data Modelling & Analysis Lab

The Lab possesses infrastructure and software for the modelling, visualisation, and comparative analysis of spatial structures which are molecular binding sites for newly developed medicines, effector molecules, and their mutual interactions. The team also has expertise in high-throughput compound analysis and protein sequencing. The Lab also develops Adamed’s own research algorithms and database software for the collection, analysis, and processing of results obtained through experiments.

Structure

Our expertise